Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86Y38 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
XT-I | - |
Homo sapiens |
xylosyltransferase-I | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | XT-I gene expression is down-regulated by IL-1beta | down |
Homo sapiens | XT-I gene expression is up-regulated by TGF-beta1 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the role of XT-I in osteoarthritis disease is examined. XT-I regulates glycosaminoglycan synthesis in human cartilage during early onset and late stage of osteoarthritis disease. Expression of XT-I gene is regulated by IL-1beta and by TGF-beta1. Forced expression of this enzyme by gene transfer in late stage osteoarthritis cartilage enhances glycosaminoglycan synthesis and stimulates cartilage repair | Homo sapiens |